Impact of gingivitis on oral health-related quality of life in 12-year-old schoolchildren of Quito, Ecuador.

PURPOSE: Evaluate the impact of gingivitis on oral health-related quality of life (OHRQoL) amongst 12-year-old schoolchildren from Quito, Ecuador. METHODS: We evaluated 998 school children using the Community Periodontal Index for gingival bleeding and calculus. OHRQoL was assessed with the Child Perceptions Questionnaire 11-14 (CPQ11-14) questionnaire. RESULTS: Of the 998 schoolchildren, 93% had gingival bleeding and 73% had dental calculus. Schoolchildren with more than one sextant with gingival bleeding had 1.18 times higher mean CPQ11-14 (RR 1.18, 95% CI 1.11-1.27) than those with none or just one affected sextant. Male schoolchildren presented a 15% lower mean Child Perceptions Questionnaire (CPQ) (RT 0.85; 95% CI 0.76-0.96). Children whose parents had incomplete secondary education had a 15% lower mean CPQ (RT 0.85; 95% CI 0.77-0.94). Bleeding in more than one sextant was significantly associated with worse quality of life in the emotional well-being (RT 1.40, 95% CI 1.03-1.90) and social well-being domains (RT 1.76, 95% CI 1.32-2.34). CONCLUSION: Gingival bleeding negatively impacted the OHRQoL of 12-year-old Ecuadorian schoolchildren living in Quito.

Anomalías de forma y número en dentición temporal en una población Mexicana / Dental anomalies of form and number in primary dentition in a Mexican population

Determinar la frecuencia y distribución de las anomalías de forma y de número en dentición temporal. Material y Métodos: Estudio retro-prolectivo, transversal y descriptivo. Muestreo probabilístico por conveniencia estratificado por género. Se revisaron 1568 expedientes de pacientes que acudieron a la Clínica de Estomatología Pediátrica de la FEBUAP, durante el periodo 2012 a 2014, se incluyeron 720 expedientes (321 niñas y 399 niños) de 1 a 10 años, que presentaron estudios radiográficos completos, nítidos, con presencia de anomalías de forma o número, el estudio fue dividido en pacientes activos e inactivos. Para los inactivos se tomaron fotografías de las radiografías con presencia de anomalías de forma y /o número. En el caso de los activos, se realizó una entrevista con alguno de los padres, se solicitó autorización bajo consentimiento informado, asentimiento por parte del niño para realizar la exploración clínica y la toma de fotografías introrales. Resultados: En total 63 niños tuvieron anomalías (17 niñas y 46 niños). La prevalencia total de las anomalías dentarias fue de 9%, de los cuales e13,1 % fueron (dientes fusionados y geminados), 1,1 % (agenesias) y 1,9% (supernumerarios), 1,3% (raíces supernumerarias), 0,27% (macrodoncia), 0,11 % (microdoncia) y finalmente el 0,27% correspondió a (talón cuspideo). Conclusiones: A pesar de que la prevalencia de estas anomalías no es alta, es importante el examen radiográfico de rutina para realizar un diagnóstico temprano y así aplicar las medidas preventivas correctas, para establecer el mejor plan de tratamiento...

To determine the frequency and distribution of dental anomalies of shape and number in primary dentition. Methods: The study is retro-prolective, cross-sectional and descriptive. The sample was probabilistic, stratified for convenience by gender. The clinical record of 1,568 patients was reviewed. These patients attended the Clinic of Pediatric Dentistry of FEBUAP during the period of 2012- 2014, only 720 records of patients were included in the study (321 girls and 399 boys) between the ages of 1-10 years old, who provided complete, crisp radiographic studies with the presence of dental anomalies of shape or number, the study was divided into active and inactive patients. For inactive patients, photographs of x-rays with dental anomalies of shape and/ or number were taken. For cases with active patients, an interview with one of the parents was conducted and authorization with informed consent was requested, also the child agreed to do a clinical examination and take intra oral photographs. Results: A total of 63 children had anomalies (17 girls and 46 boys). The total prevalence of dental anomalies was 9%, of which 3.1 % were (fused and geminated teeth), 1.1% (agenesis) and 1.9% (supernumerary), 1.3% (supernumerary roots), 0.27% (macrodontia), 0.11% (microdontia), and finally 0.27% corresponded to (talon cusp). Conclusions: Although the prevalence of these anomalies is not high, it is important to do a routine radiographic examination for early diagnosis and accordingly apply the correct preventive measures to establish the best treatment plan...

Congenital neuromuscular disease with uniform type 1 fiber and RYR1 mutation.

BACKGROUND: Congenital neuromuscular disease with uniform type 1 fiber (CNMDU1) is a rare form of congenital myopathy, which is pathologically diagnosed by the presence of more than 99% of type 1 fiber, with no specific structural changes. Its pathogenic mechanism is still unknown. We recently reported that almost all patients with central core disease (CCD) with ryanodine receptor 1 gene (RYR1) mutations in the C-terminal domain had type 1 fibers, nearly exclusively, in addition to typical central cores. OBJECTIVE: To investigate whether CNMDU1 is associated with RYR1 mutation. METHODS: We studied 10 unrelated Japanese patients who were diagnosed to have CNMDU1 based on clinical features and muscle pathology showing more than 99% type 1 muscle fibers. We extracted genomic DNA from frozen muscles and directly sequenced all 106 exons and their flanking intron-exon boundaries of RYR1. RESULTS: Four of 10 patients had a heterozygous mutation, three missense and one deletion, all in the C-terminal domain of RYR1. Two missense mutations were previously reported in CCD patients. Clinically, patients with mutations in RYR1 showed milder phenotype compared with those without mutations. CONCLUSION: Congenital neuromuscular disease with uniform type 1 fiber (CNMDU1) in 40% of patients is associated with mutations in the C-terminal domain of RYR1, suggesting that CNMDU1 is allelic to central core disease at least in some patients.